The majority of modern Formula One cars use seven-speed semi-automatic gearboxes. Regulations stipulate a maximum of seven forward gears plus reverse. Continuously Variable Transmission (CVT) systems are not allowed and cars may have no more than two driven wheels. Transmissions may not feature traction control systems, nor devices that help the driver to hold the clutch at a specific point to aid getaway at the start of the race.

For safety reasons all cars must have a means of disengaging the clutch that is operable from outside the cockpit by marshals. This control is usually situated just ahead of the cockpit opening and is marked on the car’s body by a red letter "N” within a white circle.